Publications & Research on Photobiomodulation

This 1999 review proposes cytochrome c oxidase as a photoacceptor for red and near-infrared light, identifies four primary mechanisms, and describes the secondary cascade. Review article on cells, without clinical trials.

In 1995, exposure to a helium-neon laser at 632.8 nm increased the ATP levels of cultured HeLa cells, peaking at 170.8% of the control 20 minutes after exposure. This was a laboratory study, not a clinical trial.

This 1985 review summarizes twenty years of the Mesters' work on fifteen biological systems. It states the principle that has since become a cornerstone of the field: low-energy stimulates cells, while high-energy inhibits them.

Published in 1982, this series reports on the use of lasers in 259 patients with impaired wound healing. The author describes successful outcomes in more than 90% of patients, with an average treatment duration of 10 to 12 weeks.

The third part of Mester's work on laser wound healing, this 1978 study focuses on human lymphocytes that were directly irradiated. It compares the argon laser (488–501 nm) with the helium-neon laser (632 nm).

Published in English in 1972 in a Hungarian surgical journal, this article is cited for its application to human cases. PubMed does not provide an abstract for it; therefore, no statistical data can be reported here.

Published in English in the *American Journal of Surgery* in October 1971, this article marked the international dissemination of Mester’s work. PubMed does not provide an abstract for it: no numerical data are reported here.

This 1968 article, published in German in a surgical journal, is cited as one of the first to contrast the inhibitory and activating effects of the laser. PubMed does not provide an abstract for it: no figures are reported here.

Published in German in 1968, this short article is cited in current literature as a starting point for photobiomodulation. PubMed does not provide an abstract for it; therefore, no numerical data can be reported here.